Abstract | BACKGROUND: METHODS: RESULTS: The number of anti- VEGF injections per group, visual acuity, retinal thickness, and safety measures were assessed in all groups. Thirteen patients were randomized; comparing anti- VEGF injections before and during the study, a decrease in the number of injections from 0.73 injections per month to 0.42 for daclizumab and from 0.67 to 0.34 for sirolimus was seen, while no apparent decrease was seen for either infliximab or observation. Visual acuities were maintained in all groups. CONCLUSION:
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Authors | Robert B Nussenblatt, Gordon Byrnes, H Nida Sen, Steven Yeh, Lisa Faia, Catherine Meyerle, Keith Wroblewski, Zhuqing Li, Baoying Liu, Emily Chew, Patti R Sherry, Penelope Friedman, Fred Gill, Frederick Ferris 3rd |
Journal | Retina (Philadelphia, Pa.)
(Retina)
2010 Nov-Dec
Vol. 30
Issue 10
Pg. 1579-87
ISSN: 1539-2864 [Electronic] United States |
PMID | 20847709
(Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Intramural)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Immunoglobulin G
- Immunosuppressive Agents
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Infliximab
- Daclizumab
- Sirolimus
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Topics |
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors
(administration & dosage)
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
- Choroidal Neovascularization
(drug therapy, physiopathology)
- Daclizumab
- Drug Therapy, Combination
- Female
- Humans
- Immunoglobulin G
(therapeutic use)
- Immunosuppression Therapy
- Immunosuppressive Agents
(therapeutic use)
- Infliximab
- Infusions, Intravenous
- Intravitreal Injections
- Male
- Middle Aged
- Pilot Projects
- Prospective Studies
- Recurrence
- Sirolimus
(therapeutic use)
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
- Wet Macular Degeneration
(drug therapy, physiopathology)
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