Clinical significance of early-onset hyperuricemia in renal transplant recipients.

Abstract

BACKGROUND/AIMS:

It is undetermined whether the effect of uric acid (UA) on graft outcome is independent of graft dysfunction. This study was designed to explore whether early-onset hyperuricemia has clinical significance regardless of graft function.

METHODS:

This study was conducted based on a retrospective chart review. We calculated time-averaged UA and estimated glomerular filtration rate from the values at 3, 6, and 9 months after transplantation. Cardiovascular complications during follow-up and long-term graft survival were assessed according to UA levels and graft function.

RESULTS:

351 patients were enrolled into this study. Hyperuricemia increased the risk of cardiovascular complications (HR = 2.8, 95% CI 1.1-7.1; p = 0.02), but reduced graft function did not. In the hyperuricemia group, 5- and 10-year graft survival was significantly lower than in the normouricemia group (89 and 81% vs. 96 and 92%, respectively; p = 0.02). In the reduced graft function group, these values were also lower than in the normal graft function group (89 and 81% vs. 96 and 93%, respectively; p = 0.02). In the multivariate analysis, both hyperuricemia and reduced graft function were independent risk factors for graft failure and the presence of both factors presented the highest risk.

CONCLUSION:

Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function.

• Authors: Byung Ha Chung, Seok Hui Kang, Hyeon Seok Hwang, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Ji-Il Kim, In Sung Moon, Chul Woo Yang
• Journal: Nephron. Clinical practice (Nephron Clin Pract) Vol. 117 Issue 3 Pg. c276-83 ( 2011) ISSN: 1660-2110 [Electronic] Switzerland
• PMID: 20847570 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 S. Karger AG, Basel.

Chemical References

• Uric Acid

Topics

• Adult
• Cardiovascular Diseases (blood, diagnosis, etiology)
• Female
• Follow-Up Studies
• Graft Rejection (blood, diagnosis, etiology)
• Graft Survival (physiology)
• Humans
• Hyperuricemia (blood, diagnosis, etiology)
• Kidney Transplantation (adverse effects, physiology)
• Male
• Middle Aged
• Retrospective Studies
• Time Factors
• Uric Acid (blood)