Abstract | BACKGROUND: AIM: METHODS: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. RESULTS: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. CONCLUSION: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.
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Authors | Fabian Springer, Huu Phuc Nguyen, Jürgen Machann, Roland Schweizer, Michael B Ranke, Gerhard Binder, Fritz Schick, Stefan Ehehalt, DISKUS Study Group |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 74
Issue 5
Pg. 376-80
( 2010)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 20847546
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2010 S. Karger AG, Basel. |
Topics |
- Acanthosis Nigricans
(complications, metabolism, pathology)
- Adipose Tissue
- Adolescent
- Body Mass Index
- Body Weight
(physiology)
- Choristoma
(pathology)
- Diet
- Fatty Liver
(complications, pathology)
- Female
- Humans
- Insulin Resistance
(physiology)
- Life Style
- Motor Activity
(physiology)
- Puberty
(physiology)
- Waist-Hip Ratio
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