Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSIONS: I3MO represses PDGF- and thrombin-induced VSMC proliferation and, in vivo, neointima formation, likely because it specifically blocks STAT3 signaling. This profile and its positive effect on endothelial NO production turns I3MO into a promising lead compound to prevent restenosis.
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Authors | Andrea V Schwaiberger, Elke H Heiss, Muris Cabaravdic, Tina Oberan, Jan Zaujec, Daniel Schachner, Pavel Uhrin, Atanas G Atanasov, Johannes M Breuss, Bernd R Binder, Verena M Dirsch |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 30
Issue 12
Pg. 2475-81
(Dec 2010)
ISSN: 1524-4636 [Electronic] United States |
PMID | 20847306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- Ki-67 Antigen
- Oximes
- Platelet-Derived Growth Factor
- Proto-Oncogene Proteins c-sis
- STAT3 Transcription Factor
- Stat3 protein, mouse
- Stat3 protein, rat
- indirubin-3'-monoxime
- Becaplermin
- Interferon-gamma
- Proto-Oncogene Proteins c-akt
- Mitogen-Activated Protein Kinases
- Thrombin
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Topics |
- Animals
- Arterial Occlusive Diseases
(metabolism, pathology, prevention & control)
- Becaplermin
- Cell Cycle
(drug effects)
- Cell Proliferation
- Cells, Cultured
- Constriction, Pathologic
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Endothelial Cells
(drug effects, metabolism)
- Femoral Artery
(drug effects, metabolism, pathology)
- Flow Cytometry
- Humans
- Hyperplasia
- Indoles
(pharmacology)
- Interferon-gamma
(metabolism)
- Ki-67 Antigen
(metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinases
(metabolism)
- Muscle, Smooth, Vascular
(drug effects, metabolism, pathology)
- Myocytes, Smooth Muscle
(drug effects, metabolism, pathology)
- Oximes
(pharmacology)
- Phosphorylation
- Platelet-Derived Growth Factor
(metabolism)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Proto-Oncogene Proteins c-sis
- Rats
- Rats, Sprague-Dawley
- STAT3 Transcription Factor
(antagonists & inhibitors, genetics, metabolism)
- Signal Transduction
(drug effects)
- Thrombin
(metabolism)
- Time Factors
- Transfection
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