Abstract | UNLABELLED: MATERIALS AND METHODS: 65 women diagnosed with PCOS were included to the study. I group consisted of 5 overweight PCOS women (27.2 +/- 3.6 years old; BMI 27.3 +/-1.5 kg/m2), and II group included 60 obese PCOS women (26.2 +/- 6.3 years old; BMI 35.0 +/- 4.45 kg/m2). The control group consisted of 10 healthy, ovulatory women with normal weight (aged 28.8 +/- 4.8 years; BMI 21.2 +/- 2.1 kg/m2). Folliculotrophin (FSH), lutrophin (LH), 17beta-estradiol (E2), testosterone (T), dehydroepiandrosterone sulfate (DHEAS) and insulin concentrations were measured in serum. Serum fasting glucose levels and lipid profile was assessed: total cholersterol (Ch), triglycerides (TG), low ( LDL) and high density lipoproteins (HDL). C-peptide levels were measured using commercially available test (Human C-Peptide ELISA Kit, Dako). RESULTS:
C-peptide concentrations in PCOS overweight group were 1.39 +/- 0.9, and in PCOS obese group were 1.31 +/- 1.05 nmol/I, whereas among healthy women 1.62 +/- 1.56 nmol/I. Those differences were not statistically significant. C-peptide serum levels did not correlated significantly with FSH, LH, E2, T, DHEAS serum levels within studied groups. Negative correlation between C-peptide and glucose serum levels was found in control group (R = -0.71; p < 0.05). Positive correlation between these values in PCOS overweight group was found (R = 0.90; p < 0.05). In PCOS obese group there was no correlation between these values. CONCLUSIONS:
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Authors | Marzena Maciejewska-Jeske, Arleta Szczesna, Blazej Męczekalski |
Journal | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
(Pol Merkur Lekarski)
Vol. 29
Issue 170
Pg. 93-9
(Aug 2010)
ISSN: 1426-9686 [Print] Poland |
Vernacular Title | Steienia C-peptydu w surowicy kobiet z rozpoznanym zespolem policystycznych jajników oraz towarzyszaca nadwagq lub otyloscia. |
PMID | 20842820
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- C-Peptide
(blood)
- Female
- Humans
- Obesity
(blood, complications)
- Overweight
(blood, complications)
- Polycystic Ovary Syndrome
(blood, complications)
- Reference Values
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