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Highly sensitive identification of cancer cells by combining the new tetrathiafulvalene derivative with a β-cyclodextrin/multi-walled carbon nanotubes modified GCE.

Abstract
In this contribution, we have prepared and explored a novel nano-interface based probe for the rapid identification and highly sensitive detection of cancer cells by means of an electrochemical study. The new probe tetrathiafulvalene (TTF) carboxylate salt (TTF-(COONBu(4))(2), ditetrabutylammonium salt for propylenedithio-4',5'-tetrathiafulvalene-4,5-dicarboxylate), which has specific spectral and electrochemical properties, has been synthesized and assembled with carbon nanotubes to form a new type of nanocomposite. A simple method of fabricating the β-CD/MWCNT modified electrodes based on functionalized multi-walled carbon nanotubes (MWCNTs) and β-cyclodextrin (β-CD) has been explored by using glassy carbon electrodes (GCEs), which could remarkably enhance the sensitivity of the biomolecular detection. Our results demonstrate that the combination of the new probe TTF-(COONBu(4))(2) with β-CD/MWCNT modified electrodes could be readily utilized to sensitively detect cancer cells such as liver cancer cells SMMC-7721 and HepG2, drug sensitive leukemia K562/B.W cells and drug resistant leukemia K562/ADM cells, with a detection limit of ~10(3) cells mL(-1). This may provide a novel strategy for the potential and promising application of the new TTF molecular probe in the development of multi-signal responsive biosensors for the early diagnosis of cancers.
AuthorsJuan Zhao, Jianshi Jin, Chunhui Wu, Hui Jiang, Yanyan Zhou, Jinglin Zuo, Xuemei Wang
JournalThe Analyst (Analyst) Vol. 135 Issue 11 Pg. 2965-9 (Nov 2010) ISSN: 1364-5528 [Electronic] England
PMID20838668 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Heterocyclic Compounds, 1-Ring
  • Nanotubes, Carbon
  • beta-Cyclodextrins
  • Carbon
  • betadex
Topics
  • Carbon (chemistry)
  • Cells, Cultured
  • Electrochemistry
  • Electrodes
  • Glass (chemistry)
  • Heterocyclic Compounds, 1-Ring (chemical synthesis, chemistry)
  • Humans
  • Molecular Structure
  • Nanotubes, Carbon (chemistry)
  • Neoplasms (diagnosis, pathology)
  • Particle Size
  • Sensitivity and Specificity
  • Stereoisomerism
  • Surface Properties
  • beta-Cyclodextrins (chemistry)

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