Abstract | OBJECTIVE: METHODS: RESULTS:
Aromatase was expressed in IDC and DCIS in 63 (57.3%) and 60 (67%) of the cases respectively; MMP-2 was similarly expressed in IDC and DCIS in 15 (13.60%) cases; MMP-9 was positively expressed in IDC and DCIS in 83 (75.50%) and 82 (74.50%) cases, respectively; CD44 was positively expressed in IDC and DCIS in 49 (44.50%) and 48 (42.60%) of the cases, respectively; all of them were highly correlated (p<0,001). The correlation analysis found positive, statistically significant correlation, in IDC between aromatase and MMP-2 (p<0.001) and between aromatase and MMP-9 (p=0.034). Positive correlation between aromatase and MMP-2 (p<0.001) and between MMP-9 and CD44 (p=0.030) were found in DCIS. CONCLUSION: These results allow us to conclude that aromatase through local estrogen synthesis in breast tissue plays an important role in breast carcinogenesis, mainly influencing MMP-2 and MMP-9 which are important participants in tumor cell invasion and dependence of their connection to CD44 for action.
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Authors | Fábio Bagnoli, Vilmar Marques de Oliveira, Maria Antonieta Longo Galvão da Silva, Giuliana Cássia Morrone Taromaru, José Francisco Rinaldi, Tsutomu Aoki |
Journal | Revista da Associacao Medica Brasileira (1992)
(Rev Assoc Med Bras (1992))
2010 Jul-Aug
Vol. 56
Issue 4
Pg. 472-7
ISSN: 1806-9282 [Electronic] Brazil |
PMID | 20835647
(Publication Type: Journal Article)
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Chemical References |
- CD44 protein, human
- Hyaluronan Receptors
- Neoplasm Proteins
- Aromatase
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Aromatase
(analysis, metabolism)
- Breast Neoplasms
(metabolism)
- Carcinoma in Situ
(metabolism)
- Carcinoma, Ductal, Breast
(metabolism)
- Female
- Humans
- Hyaluronan Receptors
(analysis, metabolism)
- Immunohistochemistry
- Matrix Metalloproteinase 2
(analysis, metabolism)
- Matrix Metalloproteinase 9
(analysis, metabolism)
- Neoplasm Proteins
(metabolism)
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