Evolution of locoregional treatment for peritoneal carcinomatosis: single-center experience of 308 procedures of cytoreductive surgery and perioperative intraperitoneal chemotherapy.

Abstract

BACKGROUND:

Peritoneal carcinomatosis imposes an enormous clinical burden to the oncologic community. This study reports the patterns of care of the locoregional approach of cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy as a curative procedure for peritoneal carcinomatosis from the experience of a single tertiary center in Australia.

METHODS:

We performed a review of clinical records from a prospective database of patients who were treated at the St George Hospital Peritoneal Surface Malignancy Program according to a standard protocol.

RESULTS:

A total of 308 CRS were performed in 249 patients with peritoneal surface malignancy; the mean age was 53 years and 55% were women. Over the years, we expanded the age limit for treatment (P = .03), reduced intensive care unit stays (P = .04), reduced amount of blood transfusion (P = .03), treated patients with a higher peritoneal cancer index (P < .001), achieved higher rates of complete cytoreduction (P = .003), increased use of PIC (P < .001), and improved complication rate (P = .02) and mortality rate (P = .01). The median survival of patients treated over the years also improved (P = .001).

CONCLUSIONS:

We show the maturity of the treatment of peritoneal carcinomatosis with CRS and perioperative intraperitoneal chemotherapy in our institution after an initial learning curve with expansion of the selection criteria, improved perioperative outcomes, improved surgical results, and long-term survival outcomes.

• Authors: Terence C Chua, Winston Liauw, Akshat Saxena, Khalid Al-Mohaimeed, Salawan Fransi, Jing Zhao, David L Morris
• Journal: American journal of surgery (Am J Surg) Vol. 201 Issue 2 Pg. 149-56 (Feb 2011) ISSN: 1879-1883 [Electronic] United States
• PMID: 20832051 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Appendiceal Neoplasms (pathology)
• Carcinoma (drug therapy, mortality, secondary, surgery)
• Chemotherapy, Adjuvant
• Colorectal Neoplasms (pathology)
• Drug Administration Schedule
• Female
• Humans
• Hyperthermia, Induced
• Infusions, Parenteral
• Interdisciplinary Communication
• Kaplan-Meier Estimate
• Length of Stay
• Male
• Medical Records
• Mesothelioma (drug therapy, surgery)
• Middle Aged
• Ovarian Neoplasms (pathology)
• Perioperative Period
• Peritoneal Neoplasms (drug therapy, mortality, secondary, surgery)
• Pseudomyxoma Peritonei (drug therapy, surgery)
• Retrospective Studies
• Treatment Outcome