Abstract | BACKGROUND: Little information is available about long-term outcomes of hypofractionated stereotactic radiotherapy (hypo-FSRT) for acoustic neuromas. In this study, the safety and effectiveness of hypo-FSRT for unilateral acoustic neuroma were reviewed over 8 years of experience at our institution. METHODS: Between May 1998 and October 2006, 27 patients were consecutively treated by linear accelerator-based hypo-FSRT. Two patients were excluded from this study because they were lost to follow-up within 12 months. The median follow-up period for the rest was 59 (range 24-133) months. Two types of treatment schedules were adopted. Thirteen patients received 30-39 Gy, given in 10-13 fractions (regimen A), whereas after July 2003, 12 patients received 20-24 Gy, given in 5-6 fractions at the tumor periphery ( regimen B). These treatments were scheduled to be delivered in three fractions per week (Monday, Wednesday, Friday). The median planning target volume was 2.0, with 1.7 ml (range 0.7-10.6) in regimen A and 5.2 ml (range 0.9-9.3) in regimen B. In the pretreatment audiogram, seven patients (two in regimen A and five in regimen B) had serviceable hearing (Gardner-Robertson Class I-II). RESULTS: Local control rates were 100% with regimen A and 92% with regimen B. Serviceable hearing was preserved in four of five patients in regimen B but no patients in regimen A at the last follow-up. No permanent facial or trigeminal nerve morbidity was observed following treatment, and no salvage surgery was needed. CONCLUSIONS: Hypo-FSRT for acoustic neuromas achieved a high local control rate with minimal facial and trigeminal nerve morbidity.
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Authors | Katsuyuki Sakanaka, Takashi Mizowaki, Yoshiki Arakawa, Norio Araki, Natsuo Oya, Jun A Takahashi, Nobuhiro Mikuni, Susumu Miyamoto, Nobuo Hashimoto, Masahiro Hiraoka |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 16
Issue 1
Pg. 27-32
(Feb 2011)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 20830603
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Dose Fractionation, Radiation
- Female
- Hearing Tests
- Humans
- Male
- Middle Aged
- Neuroma, Acoustic
(physiopathology, radiotherapy)
- Radiosurgery
(adverse effects, methods)
- Treatment Outcome
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