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111In-DTPA-Biotin uptake by Staphylococcus aureus.

Abstract
The potential of indium-111 labelled diethylenetriaminepentaacetic acid α,ω-bis(biocytinamide) (In-DTPA-Biotin) as a specific tracer in nuclear medicine imaging of vertebral osteomyelitis has been shown in a large series of consecutive patients. Biocytin is known to serve as a biotin source for a number of different microorganisms and quantitative studies on staphylococci indicated that on a molar basis biocytin seemed to have an activity equal to that of biotin. In this study, we evaluated the possibility of an illicit transport of In-DTPA-Biotin in cultures of Staphylococcus aureus on continued incubation for 24 h. Radiolabelled biocytin was prepared as described earlier and the stability and radiochemical purity was assessed in vitro for 24 h after labelling. Our data seem to demonstrate a passive transport of In-DTPA-Biotin into the cells of the microorganisms.
AuthorsPaola Anna Erba, Angela G Cataldi, Carlo Tascini, Alessandro Leonildi, Chiara Manfredi, Giuliano Mariani, Elena Lazzeri
JournalNuclear medicine communications (Nucl Med Commun) Vol. 31 Issue 11 Pg. 994-7 (Nov 2010) ISSN: 1473-5628 [Electronic] England
PMID20827228 (Publication Type: Journal Article)
Chemical References
  • Indium Radioisotopes
  • Biotin
  • Pentetic Acid
Topics
  • Aerobiosis
  • Biological Transport
  • Biotin (chemistry, metabolism)
  • Drug Stability
  • Indium Radioisotopes
  • Pentetic Acid (chemistry)
  • Reproducibility of Results
  • Spine (microbiology)
  • Staphylococcal Infections (metabolism)
  • Staphylococcus aureus (metabolism, physiology)
  • Time Factors

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