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Acute carbamazepine poisoning treated with resin hemoperfusion successfully.

Abstract
Carbamazepine (CBZ) poisoning has been occurring more frequently. We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). The treatment was very successful; and the patient eventually was discharged with a full recovery and no complications, although his diagnosis and treatment had been delayed for 56 hours. Hemoperfusion has a steady clearance of this drug without subsequent rebound or potential hazards. Resin hemoperfusion should be first considered for acute CBZ intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut and patient is under life-threatening condition.
AuthorsTie Gang Li, Yong Yan, Na Na Wang, Min Zhao
JournalThe American journal of emergency medicine (Am J Emerg Med) Vol. 29 Issue 5 Pg. 518-22 (Jun 2011) ISSN: 1532-8171 [Electronic] United States
PMID20825822 (Publication Type: Case Reports, Journal Article)
CopyrightCrown Copyright © 2011. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Anticonvulsants
  • Carbamazepine
Topics
  • Anticonvulsants (blood, poisoning)
  • Carbamazepine (blood, poisoning)
  • Emergency Service, Hospital
  • Glasgow Coma Scale
  • Hemoperfusion (methods)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome

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