Abstract |
Carbamazepine (CBZ) poisoning has been occurring more frequently. We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). The treatment was very successful; and the patient eventually was discharged with a full recovery and no complications, although his diagnosis and treatment had been delayed for 56 hours. Hemoperfusion has a steady clearance of this drug without subsequent rebound or potential hazards. Resin hemoperfusion should be first considered for acute CBZ intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut and patient is under life-threatening condition.
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Authors | Tie Gang Li, Yong Yan, Na Na Wang, Min Zhao |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 29
Issue 5
Pg. 518-22
(Jun 2011)
ISSN: 1532-8171 [Electronic] United States |
PMID | 20825822
(Publication Type: Case Reports, Journal Article)
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Copyright | Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anticonvulsants
- Carbamazepine
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Topics |
- Anticonvulsants
(blood, poisoning)
- Carbamazepine
(blood, poisoning)
- Emergency Service, Hospital
- Glasgow Coma Scale
- Hemoperfusion
(methods)
- Humans
- Male
- Middle Aged
- Treatment Outcome
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