Abstract | BACKGROUND: AIM: METHODS: RESULTS: CONCLUSIONS: In hepatocytes, bile acid-induced toxicity is not prevented by scavengers of oxidative stress. The beneficial effects observed in patients might be because of the contribution of ROS and cytokines rather than bile acid-mediated oxidative stress. However, the use of specific Src kinase inhibitors might be a useful tool to prevent bile acid-induced injury in liver diseases.
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Authors | Titia E Woudenberg-Vrenken, Manon Buist-Homan, Laura Conde de la Rosa, Klaas Nico Faber, Han Moshage |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 30
Issue 10
Pg. 1511-21
(Nov 2010)
ISSN: 1478-3231 [Electronic] United States |
PMID | 20825559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 John Wiley & Sons A/S. |
Chemical References |
- Antioxidants
- Protein Kinase Inhibitors
- RNA, Messenger
- Reactive Oxygen Species
- taurolithocholic acid 3-sulfate
- Taurolithocholic Acid
- Glycochenodeoxycholic Acid
- Heme Oxygenase (Decyclizing)
- Hmox1 protein, rat
- NADPH Oxidases
- src-Family Kinases
- Casp3 protein, rat
- Caspase 3
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Apoptosis
(drug effects)
- Caspase 3
(metabolism)
- Cells, Cultured
- Cytoprotection
- Glycochenodeoxycholic Acid
(metabolism)
- Heme Oxygenase (Decyclizing)
(genetics, metabolism)
- Hepatocytes
(drug effects, metabolism, pathology)
- Male
- NADPH Oxidases
(antagonists & inhibitors, metabolism)
- Necrosis
- Oxidative Stress
(drug effects)
- Protein Kinase Inhibitors
(pharmacology)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Wistar
- Rats, Zucker
- Reactive Oxygen Species
(metabolism)
- Taurolithocholic Acid
(analogs & derivatives, metabolism)
- src-Family Kinases
(antagonists & inhibitors, metabolism)
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