Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma.

Abstract

Epigenetic alterations play an important role in carcinogenesis. Recent studies have suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Global histone acetylation levels (histone H3 lysine 9 acetylation [H3K9Ac], histone H3 lysine 18 acetylation [H3K18Ac], total histone H3 acetylation [H3Ac] and total histone H4 acetylation [H4Ac]) were determined in patients with renal cell carcinoma (RCC) using immunohistochemistry in a tissue micro array with 193 RCC and 10 oncocytoma specimens. The histone acetylation pattern was not different among the diverse histological subtypes of RCC or oncocytoma samples. The H3Ac levels were inversely correlated with pT-stage (P = 0.005), distant metastasis (P = 0.036), Fuhrman grading (P = 0.001) and RCC progression (P = 0.029, hazard ratio 0.87). H4Ac deacetylation was correlated with pT-stage (P = 0.011) and grading (P = 0.029). H3K18Ac levels were an independent predictor of cancer-progression following surgery for localized RCC in the univariate (P = 0.001, hazard ratio 0.78) and multivariate (P = 0.005, hazard ratio 0.82) analysis. In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC.

• Authors: Davit Mosashvilli, Philip Kahl, Claudia Mertens, Stefanie Holzapfel, Sebastian Rogenhofer, Stefan Hauser, Reinhard Büttner, Alexander Von Ruecker, Stefan C Müller, Jörg Ellinger
• Journal: Cancer science (Cancer Sci) Vol. 101 Issue 12 Pg. 2664-9 (Dec 2010) ISSN: 1349-7006 [Electronic] England
• PMID: 20825416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2010 Japanese Cancer Association.

Chemical References

• Histones

Topics

• Acetylation
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Renal Cell (genetics, mortality, pathology)
• Epigenesis, Genetic
• Female
• Histones (genetics, metabolism)
• Humans
• Immunohistochemistry
• Kidney Neoplasms (genetics, mortality, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Tissue Array Analysis