Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the hiv infection epidemic: incidence and risk factors.

Abstract

The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

• Authors: Chia-Jui Yang, Nan-Yao Lee, Yu-Hui Lin, Hsin-Chun Lee, Wen-Chien Ko, Chun-Hsing Liao, Cheng-Hsin Wu, Chia-Ying Hsieh, Pei-Ying Wu, Wen-Chun Liu, Ya-Chu Chang, Chien-Ching Hung
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 51 Issue 8 Pg. 976-9 (Oct 15 2010) ISSN: 1537-6591 [Electronic] United States
• PMID: 20825309 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Penicillins
• Reagins

Topics

• Adolescent
• Adult
• Anti-Bacterial Agents (administration & dosage)
• Exanthema (chemically induced, epidemiology)
• Female
• Fever (chemically induced, epidemiology)
• HIV Infections (complications)
• Humans
• Incidence
• Male
• Middle Aged
• Penicillins (administration & dosage)
• Prospective Studies
• Reagins (blood)
• Risk Factors
• Syphilis (complications, drug therapy, pathology)
• Vasodilation
• Young Adult