Abstract | BACKGROUND: METHODS: We evaluated cancer as a cause of death in a US registry-based cohort of 83,282 people with AIDS (1980-2006). Causes of death due to AIDS-defining cancers (ADCs) and non-ADCs (NADCs) were assessed. We evaluated mortality rates and the fraction of deaths due to cancer. Poisson regression assessed rates according to calendar year of AIDS onset. RESULTS: Overall mortality decreased from 302 deaths per 1000 person-years in 1980-1989, to 140 deaths per 1000 person-years in 1990-1995, and to 29 deaths per 1000 person-years in 1996-2006. ADC-related mortality decreased from 2.95 deaths per 1000 person-years in 1980-1989 to 0.65 deaths per 1000 person-years in 1996-2006 (P < .01), but the fraction of ADC-related deaths increased from 1.05% to 2.47% in association with decreases in other AIDS-related deaths. Non-Hodgkin lymphoma was the most common cancer-related cause of death (36% of deaths during 1996-2006). Likewise, NADC-related mortality decreased from 2.21 to 0.84 deaths per 1000 person-years from the period 1980-1989 to the period 1996-2006 (P < .05), but the fraction of NADC-deaths increased to 3.16% during 1996-2006. Lung cancer was the most common NADC cause of death (21% of cancer-related deaths in 1996-2006). CONCLUSIONS:
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Authors | Edgar P Simard, Eric A Engels |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 51
Issue 8
Pg. 957-62
(Oct 15 2010)
ISSN: 1537-6591 [Electronic] United States |
PMID | 20825305
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
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Topics |
- Acquired Immunodeficiency Syndrome
(complications, drug therapy)
- Adult
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
(statistics & numerical data)
- Cause of Death
(trends)
- Cohort Studies
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasms
(epidemiology, mortality)
- United States
(epidemiology)
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