Abstract | BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens. We have focused on the influence of alpha-2,3-sialyltransferase ST3Gal III in key steps of the pancreatic tumorigenic process. METHODOLOGY/PRINCIPAL FINDINGS: CONCLUSION: In summary, the overexpression of ST3Gal III in these pancreatic adenocarcinoma cell lines underlines the role of this enzyme and its product in key steps of tumour progression such as adhesion, migration and metastasis formation.
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Authors | Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula |
Journal | PloS one
(PLoS One)
Vol. 5
Issue 9
(Sep 01 2010)
ISSN: 1932-6203 [Electronic] United States |
PMID | 20824144
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Sialyltransferases
- beta-Galactoside alpha-2,3-Sialyltransferase
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Topics |
- Animals
- Cell Adhesion
- Cell Line, Tumor
- Cell Movement
- Female
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Metastasis
- Neoplasm Transplantation
- Pancreatic Neoplasms
(enzymology, mortality, pathology, physiopathology)
- Rats
- Sialyltransferases
(genetics, metabolism)
- Survival
- beta-Galactoside alpha-2,3-Sialyltransferase
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