[Effect of nootropes on quantitative changes in the rat cerebral cortex GABA(A) receptor complexes under experimental hypokinesia conditions].

Abstract

The influence of picamilon and piracetam on the quantitative changes in the central GABA(A) macromolecular receptor complexes in the rat brain has been investigated under the experimental conditions of hypokinesia. It was found that the injection of these nootropes under the conditions of 7-day hypokinesia and 4-day recovery period did not show visible changes in the amount of active GABA(A) receptors. However, the injection of picamilon under the conditions of 15-day hypokinesia and 8-day recovery period showed a tendency to restoration of the number of active GABA(A) receptors.

• Authors: V P Akopian, L S Balian, N A Zakarian
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 73 Issue 7 Pg. 13-5 (Jul 2010) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 20821973 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nootropic Agents
• Receptors, GABA-A
• nicotinoyl-GABA
• gamma-Aminobutyric Acid
• Piracetam

Topics

• Animals
• Cerebral Cortex (drug effects, metabolism)
• Immobilization
• Male
• Nootropic Agents (pharmacology)
• Piracetam (pharmacology)
• Rats
• Receptors, GABA-A (metabolism)
• Time Factors
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)