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Effects of benazepril on cardiac fibrosis in STZ-induced diabetic rats.

AbstractOBJECTIVE:
The present study was designed to explore the roles of MMP-2/TIMP-2 in cardiac fibrosis and to study the effects of benazepril, an angiotensin-converting enzyme inhibitor (ACEI) on cardiac remodelling in streptozotocin(STZ)-induced diabetic rats.
METHODS AND RESULTS:
Male Wistar rats were randomly divided into three groups: a normal control group (NC), a diabetes mellitus-untreated group (DM) and a diabetes mellitus benazepril-treated group (DB). Diabetes mellitus was induced in the DM and DB groups by intraperitoneal injection of streptozotocin (60 mg/kg). DB rats were treated with benazepril 10 mg/kg/day for 12 weeks by remedial perfusing of the stomach. In the DM group, compared with the NC group, the gene and protein expression of MMP-2 decreased while the TIMP-2 gene and protein expression increased in heart tissues, along with a markedly cardiac collagen deposition.All the above changes were attenuated by benazepril treatment in the DB group.
CONCLUSIONS:
The imbalance of MMP-2 and TIMP-2 expressions in heart tissues might participate in interstitial fibrosis in diabetic myocardiopathy. Benazepril may ameliorate cardiac fibrosis partly by regulating the MMP-2/TIMP-2 system.
AuthorsQian Li, Yi Wang, Shu-zhen Sun, Yong-jie Tian, Ming-hua Liu
JournalActa cardiologica (Acta Cardiol) Vol. 65 Issue 4 Pg. 431-9 (Aug 2010) ISSN: 0001-5385 [Print] Belgium
PMID20821936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Benzazepines
  • Blood Glucose
  • Tissue Inhibitor of Metalloproteinase-2
  • Streptozocin
  • Collagen
  • Matrix Metalloproteinase 2
  • benazepril
Topics
  • Analysis of Variance
  • Angiotensin-Converting Enzyme Inhibitors (pharmacology)
  • Animals
  • Benzazepines (pharmacology)
  • Blood Glucose (metabolism)
  • Body Weight
  • Collagen (metabolism)
  • Diabetes Mellitus, Experimental (drug therapy)
  • Fibrosis (drug therapy)
  • Immunoenzyme Techniques
  • Male
  • Matrix Metalloproteinase 2 (metabolism)
  • Myocardium (pathology)
  • Organ Size
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Reverse Transcriptase Polymerase Chain Reaction
  • Staining and Labeling
  • Streptozocin
  • Tissue Inhibitor of Metalloproteinase-2 (metabolism)

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