HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Genetic alterations of the LKB1 gene in head and neck cancer.

Abstract
The genetic alterations associated with head and neck cancer (HNC) are numerous and include a variety of different pathways. It has also been shown that numerous tumor suppressor genes are involved in HNC. The LKB1 gene has been defined as a tumor suppressor gene, and somatic mutations of this gene have been identified in many different neoplasms. The aim of this study was to investigate the LKB1 gene in HNC. Nine exons of the LKB1 gene were analyzed by direct sequencing. We detected a novel missense mutation in the nuclear localization signal coding region of the LKB1 gene in 10 tumor samples from patients with HNC. Six different single-nucleotide substitutions were also observed in the introns. In two patients, a 7 bp duplication was detected in intron 3. These results indicate that the LKB1 gene may play a role in the etiology of HNC.
AuthorsEbru Kenanli, Emin Karaman, Ozgun Enver, Turgut Ulutin, Nur Buyru
JournalDNA and cell biology (DNA Cell Biol) Vol. 29 Issue 12 Pg. 735-8 (Dec 2010) ISSN: 1557-7430 [Electronic] United States
PMID20818976 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Nuclear Localization Signals
  • Protein Serine-Threonine Kinases
  • STK11 protein, human
  • AMP-Activated Protein Kinase Kinases
Topics
  • AMP-Activated Protein Kinase Kinases
  • Carcinoma, Squamous Cell (genetics)
  • Exons (genetics)
  • Female
  • Head and Neck Neoplasms (genetics)
  • Humans
  • Male
  • Middle Aged
  • Mutation, Missense
  • Nuclear Localization Signals (genetics)
  • Point Mutation
  • Protein Serine-Threonine Kinases (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: