[Nonquantal mediator secretion in the synapses of the mouse diaphragmatic preparation to the administration of sublethal doses of armin].

Abstract

During in vivo experiments on the mouse diaphragm preparations the effect of a single sublethal dose of armin (1/2 of LD50) on the dynamics of changes in acetylcholinesterase activity, frequency and time of half-decay of miniature end-plate potentials (MEPP) was studied as compared with the H-effect value. It was found that the increase of the H-effect correlated (r = 0.902) with the decrease of acetylcholinesterase activity, the increase of MEPP frequency occurring later than the changes in the enzyme activity and the H-effect value. The data obtained reveal the possible of nonquantal secretion of the mediator from the motor nerve endings of the skeletal muscles in the pathogenesis of acute poisonings with armin.

• Authors: Sh M Iakubov, S M Gorbunov, T I Oranskaia
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Nov-Dec Vol. 53 Issue 6 Pg. 19-20 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Nekvantovaia sekretsiia mediatora v sinapsakh diafragmal'nogo preparata myshi pri vvedenii subletal'nykh doz armina.
• PMID: 2081559 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Armin
• Acetylcholine

Topics

• Acetylcholine (metabolism)
• Animals
• Armin (pharmacology)
• Cholinesterase Inhibitors
• Diaphragm
• Dose-Response Relationship, Drug
• H-Reflex (drug effects, physiology)
• In Vitro Techniques
• Mice
• Microelectrodes
• Motor Endplate (drug effects, physiology)
• Quantum Theory
• Synapses (drug effects, metabolism)
• Time Factors