2,2,2-Trifluoro-N-(1a,2,7,7a-tetrahydronaphtho[2,3-b]oxiren-3-yl)acetamide by X-ray powder diffraction.

Abstract

The title compound, C(12)H(10)F(3)NO(2), an important precursor in the preparation of benzovesamicol analogues for the diagnosis of Alzheimer's disease, was prepared by the epoxidation of 5,8-dihydronaphthalen-1-amine using 3-chloroperoxybenzoic acid. The structure was determined by X-ray powder diffraction, multinuclear NMR spectroscopy and FT-IR spectroscopy. A pair of molecules form intermolecular N-H...O hydrogen bonds, involving the amino and oxirene groups, to produce a dimer.

• Authors: Mwaffak Rukiah, Thaer Assaad
• Journal: Acta crystallographica. Section C, Crystal structure communications (Acta Crystallogr C) Vol. 66 Issue Pt 9 Pg. o475-8 (Sep 2010) ISSN: 1600-5759 [Electronic] United States
• PMID: 20814111 (Publication Type: Journal Article)

Chemical References

• 2,2,2-trifluoro-N-(1a,2,7,7a-tetrahydronaphtho(2,3-b)oxiren-3-yl)acetamide
• Acetamides
• Naphthalenes

Topics

• Acetamides (chemistry)
• Dimerization
• Hydrogen Bonding
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Conformation
• Naphthalenes (chemistry)
• Spectroscopy, Fourier Transform Infrared
• X-Ray Diffraction