[Clinical and ultrastructural studies on 8 cases of methamidophos toxicologic myopathy].

Abstract

Clinically, there was pain or numbness in the lower limbs at first; then followed by muscular weakness and symmetrical wasting of the small muscles of the hands and lower limbs. Electromyography showed myogenic changes in all the 8 cases and biopsies indicated atrophy of muscle fibers. The most prominent ultrastructural change was presence of abnormal accumulation of myofibers with regeneration and necrosis. There was decrease of mitochondria and glycogen even disappearance of M--line or Z--line. The pathogenesis is considered due to cell--mediated--immunity and direct toxic effect.

• Authors: Z S Wu
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 19 Issue 4 Pg. 303-5 (Dec 1990) ISSN: 0529-5807 [Print] China
• PMID: 2081358 (Publication Type: English Abstract, Journal Article)

Chemical References

• Insecticides
• Organothiophosphorus Compounds
• Dexamethasone
• methamidophos

Topics

• Adult
• Dexamethasone (therapeutic use)
• Female
• Humans
• Insecticides (poisoning)
• Male
• Mitochondria, Muscle (ultrastructure)
• Muscles (ultrastructure)
• Muscular Diseases (chemically induced, drug therapy, pathology)
• Organothiophosphorus Compounds (poisoning)