Abstract | OBJECTIVE: STUDY DESIGN: Forty-two human immunodeficiency virus-positive patients with 69 OHL lesions were randomly treated using P, PA, or PP (14 patients in each topical treatment protocol). Clinical healing was determined when the white plaque could no longer be seen in the primary location of the lesion. Topical treatment performance was evaluated by clinical healing within each week of topical treatment protocol as well as by the recurrence of the lesion. Statistical survival analysis was performed using a Cox proportional hazards model. RESULTS: Approximately 55% of the patients presented with clinical healing of OHL within 7-8 weeks of each topical treatment protocol. After the sixth week, the PA treatment protocol presented a faster clinical healing rate of OHL. Recurrence was observed in 3 and 7 OHL lesions treated with P and PP treatment protocols, respectively. CONCLUSIONS: The PP treatment protocol proved to be effective; however, the PA treatment protocol was more effective in the clinical healing rate for OHL than P and PP after the sixth week of treatment, and no recurrent OHL was observed in the PA treatment group.
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Authors | Mariela Dutra Gontijo Moura, João Paulo Amaral Haddad, Maria Inês Barreiros Senna, Efigênia Ferreira e Ferreira, Ricardo Alves Mesquita |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 110
Issue 5
Pg. 611-7
(Nov 2010)
ISSN: 1528-395X [Electronic] United States |
PMID | 20813564
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Mosby, Inc. All rights reserved. |
Chemical References |
- Antifungal Agents
- Antineoplastic Agents, Phytogenic
- Antiviral Agents
- penciclovir
- Guanine
- Podophyllin
- Acyclovir
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Topics |
- Acyclovir
(administration & dosage, analogs & derivatives)
- Administration, Topical
- Adult
- Antifungal Agents
(therapeutic use)
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Antiviral Agents
(administration & dosage)
- Candidiasis, Oral
(complications, drug therapy)
- Double-Blind Method
- Female
- Follow-Up Studies
- Guanine
- HIV Infections
(complications, transmission)
- HIV Seropositivity
(complications, transmission)
- Heterosexuality
- Humans
- Leukoplakia, Hairy
(drug therapy)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(pathology)
- Podophyllin
(administration & dosage)
- Proportional Hazards Models
- Remission Induction
- Time Factors
- Tongue Neoplasms
(drug therapy)
- Treatment Outcome
- Young Adult
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