Abstract | OBJECTIVE: Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. DESIGN/METHODS: Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male precocious puberty ( FMPP) underwent a semi-structured psychiatric interview, the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. According to sex and the literature, incidence of identified psychopathology was compared between the two endocrinological groups. We evaluated 72 patients: 54 CAH (21 females) and 18 FMPP. RESULTS: CONCLUSION: Although anxiety disorders may occur at an increased rate in children with chronic illness, androgens may contribute to higher risk for psychopathology in pediatric patients with genetic cause of excess androgen. Early diagnosis and treatment of childhood hyperandrogenism is essential for optimal development. The results suggest that assessment for psychiatric disorders should be part of the routine evaluation of these patients.
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Authors | Sven C Mueller, Pamela Ng, Ninet Sinaii, Ellen W Leschek, Liza Green-Golan, Carol VanRyzin, Monique Ernst, Deborah P Merke |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 163
Issue 5
Pg. 801-10
(Nov 2010)
ISSN: 1479-683X [Electronic] England |
PMID | 20807778
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adrenal Hyperplasia, Congenital
(diagnosis, genetics, psychology)
- Anxiety
(diagnosis, genetics, psychology)
- Attention Deficit Disorder with Hyperactivity
(diagnosis, genetics, psychology)
- Child
- Female
- Humans
- Hyperandrogenism
(complications, diagnosis, genetics, psychology)
- Male
- Mental Disorders
(diagnosis, genetics, psychology)
- Puberty, Precocious
(diagnosis, genetics, psychology)
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