Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida.

Abstract

A Phormidium spp. collection from Key West, Florida, afforded caylobolide B (1), an analogue of the known macrolactone caylobolide A, previously isolated from a Lyngbya majuscula collection from the Bahamas. The planar structure of 1 was determined using NMR and MS experiments. The relative configuration for subunits C7-C9 and C25-C29 was assigned using Kishi's Universal NMR Database. Caylobolide B (1) displayed cytotoxic activity against HT29 colorectal adenocarcinoma and HeLa cervical carcinoma cells with IC(50) values of 4.5 and 12.2 μM, respectively.

• Authors: Lilibeth A Salvador, Valerie J Paul, Hendrik Luesch
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 9 Pg. 1606-9 (Sep 24 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20806908 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antineoplastic Agents
• Depsipeptides
• Lactones
• caylobolide A
• caylobolide B
• symplostatin 1

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Bahamas
• Cyanobacteria (chemistry)
• Depsipeptides (chemistry, isolation & purification)
• Drug Screening Assays, Antitumor
• Female
• Florida
• HT29 Cells
• HeLa Cells
• Humans
• Inhibitory Concentration 50
• Lactones (chemistry, isolation & purification, pharmacology)
• Marine Biology
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular