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Decreasing expression of the interleukin-13 receptor IL-13Ralpha2 in treated recurrent malignant gliomas.

Abstract
The IL-13Ralpha2 gene encodes for a 65 kDa protein that forms one of the subunits of the interleukin-13 (IL-13) receptor. This gene is highly expressed in various types of human tumors including malignant gliomas. The expression level of IL-13Ralpha2 was examined in a total of 45 tissue samples of anaplastic astrocytomas (AAs) World Health Organization (WHO) grade III, glioblastomas (GBMs) WHO grade IV, and first-recurrent glioblastomas (frGBMs) after treatment with radiation and chemotherapy. IL-13Ralpha2 expression was detected by semiquantitative reverse transcription real-time polymerase chain reaction (PCR) using ABI PRISM 7700 and Qiagen QuantiTect SYBR Green PCR kits. The expression level of IL-13Ralpha2 (15 fold) was significantly reduced in frGBMs compared to the primary GBMs (p = 0.014), and significantly reduced by more than 15 fold (p = 0.003) in all untreated malignant astrocytomas (AAs and GBMs) compared with treated frGBMs. Expression of IL-13Ralpha2 seems to be lower in frGBMs compared to GBMs. The promising antitumor effect of IL-13 cytotoxin could be greatly reduced in frGBM or only achievable with higher amounts of cytotoxin, due to the significantly lower expression of the cytotoxin's target structure.
AuthorsOliver Bozinov, Jens-Martin Kalk, Niklaus Krayenbühl, Christoph Michael Woernle, Ulrich Sure, Helmut Bertalanffy
JournalNeurologia medico-chirurgica (Neurol Med Chir (Tokyo)) Vol. 50 Issue 8 Pg. 617-21 ( 2010) ISSN: 1349-8029 [Electronic] Japan
PMID20805641 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Actins
  • Exotoxins
  • IL13-PE38
  • Immunotoxins
  • Interleukin-13
  • Interleukin-13 Receptor alpha2 Subunit
  • Recombinant Fusion Proteins
  • Nimustine
  • RNA
  • Teniposide
Topics
  • Actins (genetics, metabolism)
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Astrocytoma (metabolism, pathology, therapy)
  • Brain Neoplasms (metabolism, pathology, therapy)
  • Exotoxins (therapeutic use)
  • Female
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Glioblastoma (metabolism, pathology, therapy)
  • Humans
  • Immunotoxins (therapeutic use)
  • Interleukin-13 (therapeutic use)
  • Interleukin-13 Receptor alpha2 Subunit (genetics, metabolism)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (metabolism, pathology)
  • Nimustine (administration & dosage)
  • RNA (analysis)
  • Recombinant Fusion Proteins
  • Teniposide (administration & dosage)
  • Young Adult

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