Macrocycles as a tool: a facile and one-pot synthesis of silver nanoparticles using cucurbituril designed for cancer therapeutics.

Abstract

Silver nanoparticles made easy: A simple, effective, and one-pot method toward the synthesis of a defined macrocycle-silver nanoparticle system in water has been described (see figure). Interestingly, cucurbituril (CB)[7]-protected AgNPs showed significantly increased cytotoxicity against MCF-7 and NCI-H358 cancer cells, as demonstrated by models in vitro.

• Authors: Thathan Premkumar, Yeonju Lee, Kurt E Geckeler
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 16 Issue 38 Pg. 11563-6 (Oct 11 2010) ISSN: 1521-3765 [Electronic] Germany
• PMID: 20803582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Bridged-Ring Compounds
• Imidazoles
• cucurbit(7)uril
• Water
• Silver
• Sodium Hydroxide

Topics

• Bridged-Ring Compounds (chemistry, therapeutic use)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Imidazoles (chemistry, therapeutic use)
• MCF-7 Cells
• Metal Nanoparticles (chemistry, toxicity)
• Neoplasms (drug therapy)
• Particle Size
• Silver (chemistry)
• Sodium Hydroxide (chemistry)
• Water (chemistry)