Abstract | PURPOSE: PATIENTS AND METHODS: The subjects were 51 patients with esophageal cancer who were treated between 1985 and 2005 using proton beams with or without X-rays. All but one had squamous cell carcinoma. Of the 51 patients, 33 received combinations of X-rays (median 46 Gy) and protons (median 36 GyE) as a boost. The median total dose of combined X-rays and proton radiation for these 33 patients was 80 GyE (range 70-90 GyE). The other 18 patients received proton-beam therapy alone (median 79 GyE, range 62-98 GyE). RESULTS: Treatment interruption due to radiation-induced esophagitis or hematologic toxicity was not required for any patient. The overall 5-year actuarial survival rate for the 51 patients was 21.1% and the median survival time was 20.5 months (95% confidence interval 10.9-30.2). Of the 51 patients, 40 (78%) showed a complete response within 4 months after completing treatment and seven (14%) showed a partial response, giving a response rate of 92% (47/51). The 5-year local control rate for all 51 patients was 38.0% and the median local control time was 25.5 months (95% confidence interval 14.6-36.3). CONCLUSION:
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Authors | Masashi Mizumoto, Shinji Sugahara, Hidetsugu Nakayama, Haruko Hashii, Akira Nakahara, Hideo Terashima, Toshiyuki Okumura, Koji Tsuboi, Koichi Tokuuye, Hideyuki Sakurai |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 186
Issue 9
Pg. 482-8
(Sep 2010)
ISSN: 1439-099X [Electronic] Germany |
PMID | 20803187
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Esophageal Neoplasms
(pathology, radiotherapy, surgery)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Proton Therapy
- Survival Rate
- Treatment Outcome
- X-Rays
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