Abstract | BACKGROUND: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use of molecular biomarkers may enhance the sensitivity of cytologic examination in the detection of lung cancer. METHODS: RESULTS: There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. The sensitivity and specificity of the factor H test was 82% and 77%, respectively. These results were validated in an independent set of patients with nearly identical results. Furthermore, 70% and 45% of bronchoalveolar lavage fluids from central and peripheral tumors, respectively, reported as cytologically negative, were classified as positive using this marker. Finally, the test was evaluated in a series of sputum supernatants from lung cancer patients and controls. The sensitivity and specificity of the factor H test in this series was 80% and 88%, respectively. CONCLUSION: IMPACT:
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Authors | Ruben Pio, Javier Garcia, Leticia Corrales, Daniel Ajona, Michael Fleischhacker, Maria J Pajares, Felipe Cardenal, Luis Seijo, Javier J Zulueta, Ernest Nadal, Christian Witt, Maria D Lozano, Bernd Schmidt, Luis M Montuenga |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 19
Issue 10
Pg. 2665-72
(Oct 2010)
ISSN: 1538-7755 [Electronic] United States |
PMID | 20802023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | ©2010 AACR. |
Chemical References |
- Biomarkers, Tumor
- Complement Factor H
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Topics |
- Biomarkers, Tumor
(metabolism)
- Bronchoalveolar Lavage Fluid
(immunology)
- Bronchoscopy
(methods)
- Cohort Studies
- Complement Factor H
(metabolism)
- Female
- Humans
- Lung Neoplasms
(diagnosis, immunology, pathology)
- Male
- Middle Aged
- Sensitivity and Specificity
- Sputum
(immunology)
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