Abstract | BACKGROUND & AIMS: METHODS: RESULTS: Fifty-two patients were randomized in the study (28 into the N-acetylcysteine arm, 24 into the control arm), and among them, five were excluded from the analysis for protocol violation. The two groups did not differ in baseline characteristics. Survival rates at 1 and 6 months in N-acetylcysteine and control groups were 70.2 vs. 83.8% (p=0.26) and 62.4 vs. 67.1% (p=0.60), respectively. Early biological changes, documented infection rate at 1 month, and incidence of hepatorenal syndrome did not differ between the two groups. CONCLUSIONS:
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Authors | Christophe Moreno, Philippe Langlet, Axel Hittelet, Luc Lasser, Delphine Degré, Sylvie Evrard, Isabelle Colle, Arnaud Lemmers, Jacques Devière, Olivier Le Moine |
Journal | Journal of hepatology
(J Hepatol)
Vol. 53
Issue 6
Pg. 1117-22
(Dec 2010)
ISSN: 1600-0641 [Electronic] Netherlands |
PMID | 20801542
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Free Radical Scavengers
- Acetylcysteine
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Topics |
- Acetylcysteine
(administration & dosage, therapeutic use)
- Adult
- Combined Modality Therapy
- Enteral Nutrition
- Female
- Free Radical Scavengers
(administration & dosage, therapeutic use)
- Hepatitis, Alcoholic
(drug therapy, therapy)
- Hepatorenal Syndrome
(prevention & control)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
- Single-Blind Method
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