Postoperative recurrence as an associated factor of malignant transformation of oral dysplastic leukoplakia.

Abstract

PURPOSE:

To evaluate the clinically associated factors of malignant transformation in patients who received laser surgery for oral dysplastic leukoplakia.

PROCEDURES:

The clinicopathological data of patients receiving laser surgery for dysplastic leukoplakia from 2002 to 2008 and HPV genomic DNA extracted from paraffin-embedded specimens were analyzed statistically.

RESULTS:

A total 114 patients, 90 males and 24 females with an average age of 49.7 ± 12.2 years were enrolled. The follow-up period ranged from 1.07 to 7.43 years (mean 3.4 ± 1.3 years). Thirteen cases had malignant transformation (11.4%). Multiple-focus lesions, non-homogeneous leukoplakia, high-grade dysplasia and recurrence after laser treatment were significant factors in univariate analysis. Multivariate analysis showed that recurrence (relative risk = 9.40) was the independent prognostic factor for malignant transformation.

CONCLUSIONS:

Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia.

• Authors: Shih-Wei Yang, Chang-Jer Wu, Yun-Shien Lee, Tai-An Chen, Chi-Neu Tsai
• Journal: ORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 72 Issue 5 Pg. 280-90 ( 2010) ISSN: 1423-0275 [Electronic] Switzerland
• PMID: 20798565 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Cell Transformation, Neoplastic
• Female
• Humans
• Laser Therapy (statistics & numerical data)
• Lasers, Gas
• Leukoplakia, Oral (epidemiology, pathology, surgery)
• Male
• Middle Aged
• Mouth Neoplasms (epidemiology, pathology, surgery)
• Neoplasm Recurrence, Local (epidemiology, pathology)
• Neoplasms, Squamous Cell (epidemiology, pathology, surgery)
• Postoperative Complications (epidemiology, pathology)
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Risk Factors