Pseudolymphoma and cutaneous lymphoma: facts and controversies.

Cutaneous pseudolymphoma refers to a heterogenous group of benign reactive T-cell or B-cell lymphoproliferative processes of diverse causes that simulate cutaneous lymphomas clinically and histologically. Pseudolymphomas may arise in response to a wide variety of foreign antigens, but most are idiopathic. Major advances have been made in the histologic classification, immunohistochemistry, and molecular studies of cutaneous pseudolymphoma. Although this enables a more precise differentiation from cutaneous lymphoma, a substantial number of patients still present in whom the differential diagnosis is difficult or impossible. Some evidence suggests that pseudolymphomas may progress to cutaneous lymphoma due to persistent antigenic stimulation. More compelling evidence is needed, especially when most cutaneous pseudolymphoma are not associated with known antigens and the differentiation from cutaneous lymphoma may be difficult; therefore, a careful approach should be used, and the antigenic stimulus should be removed whenever possible. A watchful follow-up is warranted in idiopathic cases, and consideration should always be given to surgical or medical therapy.
AuthorsReuven Bergman
JournalClinics in dermatology (Clin Dermatol) 2010 Sep-Oct Vol. 28 Issue 5 Pg. 568-74 ISSN: 1879-1131 [Electronic] United States
PMID20797521 (Publication Type: Journal Article)
CopyrightCopyright 2010 Elsevier Inc. All rights reserved.
  • Diagnosis, Differential
  • Female
  • Humans
  • Lymphoma, B-Cell (diagnosis, pathology)
  • Lymphoma, T-Cell, Cutaneous (diagnosis, pathology)
  • Pseudolymphoma (diagnosis, pathology)
  • Skin Neoplasms (diagnosis, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: