[The prognostic value of detection of serum VEGF-C level and lymphangiogenesis in mediastinal lymph nodes in the patients with lung cancer.].

Abstract

BACKGROUND:

There is still lack of special prognostic factor on lung cancer, this study will explore the prognostic value of serum VEGF-C level and lymphangiogenesis of primary cancer and mediastinal lymph nodes in the patients with lung cancer.

METHODS:

Thirty patients with NSCLC would accept operation (new group) and 30 cases followed up three years postoperative (history group) were chosen respectively. The serum VEGF-C level of new group was tested. The VEGF-C and LYVE-1 expression in the mediastinal lymph nodes were put in practice between two groups. The relationship was analyzed for the serum VEGF-C level, VEGF-C and LYVE-1 expression of primary cancer and mediastinal lymph nodes, mediastinal lymph nodes metastasis and the 3-year survival rate of the patients.

RESULTS:

(1)In new group, the serum VEGF-C level of N2 patients was significantly higher than that of non-N2 patients. (2)In new group, the serum VEGF-C level was closely correlated with VEGF-C expression of primary cancer. (3)In two groups, the primary cancer and mediastinal metastasis lymph nodes had high VEGF-C expression. (4)VEGF-C expression of primary cancer and mediastinal lymph nodes was closely correlated with LYVE-1 expression between the two groups. (5)VEGF-C and LYVE-1 expression of N2 patients was significantly higher than that of non-N2 patients between two groups. (6)The patients' 3-year-survival rate was closely correlated with VEGF-C expression of primary cancer and mediastinal lymph nodes metastasis.

CONCLUSIONS:

Serum VEGF-C level has close correlation with VEGF-C expression of primary cancer, lymphangiogenesis of primary cancer/mediastinal lymph nodes, mediastinal lymph nodes metastasis status and patient's survival rate. Serum VEGF-C level is possible to be used as prognostic factor on lung cancer.

• Authors: Yang Shen-Tu, Tiancheng Zhao, Zhengping Ding, Yunzhong Zhou
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 11 Issue 6 Pg. 769-74 (Dec 20 2008) ISSN: 1999-6187 [Electronic] China
• PMID: 20797326 (Publication Type: English Abstract, Journal Article)