Abstract | OBJECTIVES: The objective of the present study was to evaluate a novel mucoadhesive polymer extracted from Bletilla striata for ocular delivery of 0.5% levofloxacin in rabbits, and to determine its improved efficacy against experimental keratitis. METHODS: KEY FINDINGS: BsP markedly increased the proliferative capacity of a human corneal epithelial [corrected] cell line. The ferning test showed that BsP exhibited optimal performance as a tear fluid. The polysaccharides significantly increased intra-aqueous penetration and corneal accumulation in rabbits. Treatment with levofloxacin-BsP reduced the number of organisms more significantly than eye drops containing levofloxacin alone. CONCLUSIONS: BsP appears to be a promising candidate as a vehicle for topical ophthalmic drug delivery, especially for antibiotics.
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Authors | Xiang-gen Wu, Meng Xin, Hao Chen, Li-na Yang, Hao-ran Jiang |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 62
Issue 9
Pg. 1152-7
(Sep 2010)
ISSN: 2042-7158 [Electronic] England |
PMID | 20796194
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Ophthalmic Solutions
- Plant Extracts
- Polysaccharides
- Levofloxacin
- Ofloxacin
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Topics |
- Absorption
- Administration, Topical
- Animals
- Anti-Bacterial Agents
(pharmacokinetics, pharmacology, therapeutic use)
- Aqueous Humor
(drug effects)
- Bacterial Load
- Biological Availability
- Cell Line
- Cell Proliferation
(drug effects)
- Cornea
(cytology, drug effects)
- Disease Models, Animal
- Endothelial Cells
(drug effects, physiology)
- Eye
(cytology, drug effects)
- Female
- Humans
- Keratitis
(drug therapy, microbiology)
- Levofloxacin
- Male
- Ofloxacin
(pharmacokinetics, pharmacology, therapeutic use)
- Ophthalmic Solutions
- Orchidaceae
(chemistry)
- Plant Extracts
(pharmacology)
- Polysaccharides
(isolation & purification, pharmacology)
- Rabbits
- Staphylococcal Infections
(drug therapy)
- Staphylococcus aureus
(drug effects)
- Tears
- Treatment Outcome
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