HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tumor accumulation mechanism of 99mTc-DL-homocysteine, a model compound for the development of tumor-imaging radiopharmaceuticals.

Abstract
To elucidate the tumor accumulation mechanism of 99mTc-DL-homocysteine (99mTc-Hcy), the role of mercaptalbumin, a carrier protein of 99mTc-Hcy in blood, was studied. 99mTc-Hcy bound to serum mercaptalbumin was carried to tumor tissue, efficiently adsorbed onto the cell surface, released from albumin, and taken up by the cells. An enlarged capillary permeability observed in tumor tissue played an important role in the transport process.
AuthorsA Takeda, T Hibino, A Hoshino, S Okada
JournalInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 17 Issue 8 Pg. 751-5 ( 1990) ISSN: 0883-2897 [Print] England
PMID2079421 (Publication Type: Journal Article)
Chemical References
  • Carrier Proteins
  • Organotechnetium Compounds
  • Serum Albumin
  • mercaptoalbumin
  • technetium Tc 99m homocysteine
  • Homocysteine
Topics
  • Animals
  • Capillary Permeability (physiology)
  • Carcinoma, Ehrlich Tumor (metabolism, physiopathology)
  • Carrier Proteins (physiology)
  • Homocysteine (pharmacokinetics)
  • Male
  • Mice
  • Organotechnetium Compounds (pharmacokinetics)
  • Serum Albumin (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: