Abstract |
To elucidate the tumor accumulation mechanism of 99mTc-DL-homocysteine (99mTc-Hcy), the role of mercaptalbumin, a carrier protein of 99mTc-Hcy in blood, was studied. 99mTc-Hcy bound to serum mercaptalbumin was carried to tumor tissue, efficiently adsorbed onto the cell surface, released from albumin, and taken up by the cells. An enlarged capillary permeability observed in tumor tissue played an important role in the transport process.
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Authors | A Takeda, T Hibino, A Hoshino, S Okada |
Journal | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
(Int J Rad Appl Instrum B)
Vol. 17
Issue 8
Pg. 751-5
( 1990)
ISSN: 0883-2897 [Print] England |
PMID | 2079421
(Publication Type: Journal Article)
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Chemical References |
- Carrier Proteins
- Organotechnetium Compounds
- Serum Albumin
- mercaptoalbumin
- technetium Tc 99m homocysteine
- Homocysteine
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Topics |
- Animals
- Capillary Permeability
(physiology)
- Carcinoma, Ehrlich Tumor
(metabolism, physiopathology)
- Carrier Proteins
(physiology)
- Homocysteine
(pharmacokinetics)
- Male
- Mice
- Organotechnetium Compounds
(pharmacokinetics)
- Serum Albumin
(physiology)
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