Decreased activity of liver coproporphyrinogen oxidase in hexachlorobenzene-induced porphyria.

Abstract

A 2.5-time decrease of hepatic coproporphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyrin.

• Authors: D G Adjarov
• Journal: Experimental pathology (Exp Pathol) Vol. 40 Issue 2 Pg. 117-22 ( 1990) ISSN: 0232-1513 [Print] Germany
• PMID: 2079105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coproporphyrins
• Hexachlorobenzene
• Coproporphyrinogen Oxidase

Topics

• Animals
• Chromatography, High Pressure Liquid
• Coproporphyrinogen Oxidase (metabolism)
• Coproporphyrins (metabolism)
• Hexachlorobenzene (adverse effects)
• Hydrogen-Ion Concentration
• Liver (enzymology)
• Male
• Mice
• Mice, Inbred C57BL
• Oxidation-Reduction
• Porphyrias (chemically induced, enzymology)
• Time Factors