Abstract |
The effects of superoxide dismutase modified with polyoxyethylene ( SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. SOD-POE or saline was administered i.v. 30 min before reperfusion. Changes in hemodynamic variables and SS by CSPT were similar in both groups. However, the SOD-POE group showed improved recovery of SS compared with the control group. Results indicate that oxygen-derived free radicals may partially be involved in the genesis of myocardial dysfunction after CSPT-induced regional ischemia.
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Authors | K Noguchi, Y Ojiri, N Kinjo, H Moromizato, J Nakasone, M Sakanashi |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 54
Issue 2
Pg. 244-9
(Oct 1990)
ISSN: 0021-5198 [Print] Japan |
PMID | 2077188
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Polyethylene Glycols
- Superoxide Dismutase
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Topics |
- Animals
- Coronary Disease
(etiology, physiopathology)
- Coronary Vessels
(drug effects)
- Dogs
- Female
- Heart
(drug effects, physiology)
- Hemodynamics
(physiology)
- Male
- Myocardial Reperfusion
- Polyethylene Glycols
(pharmacology)
- Superoxide Dismutase
(pharmacology)
- Tachycardia
(etiology)
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