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Effect of polyoxyethylene-modified superoxide dismutase on recovery of myocardial dysfunction after coronary stenosis in dogs.

Abstract
The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. SOD-POE or saline was administered i.v. 30 min before reperfusion. Changes in hemodynamic variables and SS by CSPT were similar in both groups. However, the SOD-POE group showed improved recovery of SS compared with the control group. Results indicate that oxygen-derived free radicals may partially be involved in the genesis of myocardial dysfunction after CSPT-induced regional ischemia.
AuthorsK Noguchi, Y Ojiri, N Kinjo, H Moromizato, J Nakasone, M Sakanashi
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 54 Issue 2 Pg. 244-9 (Oct 1990) ISSN: 0021-5198 [Print] Japan
PMID2077188 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Polyethylene Glycols
  • Superoxide Dismutase
Topics
  • Animals
  • Coronary Disease (etiology, physiopathology)
  • Coronary Vessels (drug effects)
  • Dogs
  • Female
  • Heart (drug effects, physiology)
  • Hemodynamics (physiology)
  • Male
  • Myocardial Reperfusion
  • Polyethylene Glycols (pharmacology)
  • Superoxide Dismutase (pharmacology)
  • Tachycardia (etiology)

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