Effects of a novel Hungarian antacid containing Al and Mg (Tisacid) on mucosal prostaglandin generation and oxygen free radicals in normal rats.

Abstract

A new patented chemical agent (Al-Mg-hydroxy-carbonate; acid-binding capacity greater than 30 mmol/g) was produced by our work-team. After our preliminary pharmacological and some prospective, randomized, multicentre, controlled clinical studies, this antacid was registered (Tisacid tablet and suspension; Alkaloida, Hungary). A cumulative ulcer healing rate of 80-85% was proved by Tisacid monotherapy applied in low doses (from 80 to 160 mmol/day) in patients with duodenal ulcer. The aims of this study were: (i) to determine the role of different antacids on the genesis of mucosal prostaglandins (PGs) (PGE2 and 6-keto-PGF1 alpha) in normal rats; (ii) to evaluate the effects of indomethacin pre-treatment (20 mg/kg b.w.,s.c.) on the Tisacid-induced alterations of gastric mucosal PG-contents; (iii) to analyse the generation of oxygen free radicals and lipid peroxidation in the rat oxyntic mucosa by the application of different doses of Tisacid (activities of CAT, GSH-px and SOD, contents of MDA and red. GSH). It was found that: Tisacid has a potent gastroproprotective effect in gastric mucosa, via (a) an increase in the mucosal levels of PGs, and (b) a scavenging-like effect in normal rat gastric mucosa. It is concluded that the gastroprotective effect of Tisacid appears because of the following: (i) excellent acid-neutralizing capacity; (ii) mucosal generation of PGs (PGE2 and PGI2); (iii) free radical scavenging; (iv) its possible activity as a Ca-antagonist (Mg-containing compound).

• Authors: L Nagy, G Mózsik, A Vincze, Süto G, B Hunyady, J Rinfel, T Past, T Jávor
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 16 Issue 4 Pg. 197-203 ( 1990) ISSN: 0378-6501 [Print] Switzerland
• PMID: 2076656 (Publication Type: Journal Article)

Chemical References

• Antacids
• Carbonates
• Free Radicals
• Prostaglandins
• Malondialdehyde
• almagate
• 6-Ketoprostaglandin F1 alpha
• Aluminum Hydroxide
• Glutathione
• Dinoprostone
• Magnesium Hydroxide
• Oxygen
• Indomethacin

Topics

• 6-Ketoprostaglandin F1 alpha (biosynthesis)
• Aluminum Hydroxide (pharmacology)
• Animals
• Antacids (pharmacology)
• Carbonates (pharmacology)
• Dinoprostone (biosynthesis)
• Dose-Response Relationship, Drug
• Female
• Free Radicals
• Gastric Mucosa (anatomy & histology, drug effects, metabolism)
• Glutathione (metabolism)
• Indomethacin (pharmacology)
• Lipid Peroxidation
• Magnesium Hydroxide (pharmacology)
• Male
• Malondialdehyde (metabolism)
• Oxygen (metabolism)
• Prostaglandins (biosynthesis)
• Rats
• Rats, Inbred Strains
• Time Factors