Effects of nifedipine on cardiac function in patients with coronary artery disease evaluated with ambulatory radionuclide monitoring.

The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine administration. The heart rate increased and the resting systolic blood pressure decreased significantly with nifedipine. The end-diastolic and end-systolic volumes during exercise were significantly reduced and EF increased during exercise after nifedipine administration. These salutary hemodynamic responses of nifedipine appear to be beneficial for patients with effort angina pectoris.
AuthorsH Kambara, I H Mohiuddin, N Tamaki, T Fudo, M Hayashi, R Nohara, J Konishi, C Kawai
JournalCardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (Cardiovasc Drugs Ther) Vol. 4 Suppl 5 Pg. 919-22 (Aug 1990) ISSN: 0920-3206 [Print] UNITED STATES
PMID2076400 (Publication Type: Journal Article)
Chemical References
  • Nifedipine
  • Aged
  • Coronary Disease (drug therapy, physiopathology)
  • Exercise Test
  • Female
  • Heart (drug effects, physiopathology, radionuclide imaging)
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Monitoring, Physiologic (methods)
  • Nifedipine (pharmacology)
  • Ventricular Function, Left (drug effects)

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