Effect of testosterone on adrenal corticosteroidogenesis in lithium treated male rats.

Abstract

Lithium chloride at a dose of 200 micrograms/100 g body weight/day given for 21 days caused a significant increase in adrenal weight, adrenal 5-ene-3 beta-hydroxysteroid dehydrogenase (5-ene-3 beta-HSD) activity along with elevation in serum level of corticosterone on the 22nd day in the rat. Administration of testosterone for the last 14 days to lithium treated rats caused a significant decrease in adrenal weight, adrenal 5-ene-3 beta-HSD activity and serum level of corticosterone in comparison to lithium treated animals.

• Authors: D Ghosh, N M Biswas, A Chaudhuri, P K Ghosh
• Journal: Acta physiologica Hungarica (Acta Physiol Hung) Vol. 75 Issue 4 Pg. 267-70 ( 1990) ISSN: 0231-424X [Print] Hungary
• PMID: 2075823 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Testosterone
• Lithium
• 3-Hydroxysteroid Dehydrogenases
• delta(5)-3 beta-hydroxysteroid dehydrogenase
• Corticosterone

Topics

• 3-Hydroxysteroid Dehydrogenases (metabolism)
• Adrenal Cortex Hormones (biosynthesis)
• Adrenal Glands (drug effects, enzymology, metabolism)
• Animals
• Corticosterone (blood)
• Lithium (pharmacology)
• Male
• Organ Size (drug effects)
• Rats
• Testosterone (pharmacology)