[Activity of alkaline phospholipase A in lysosomes and mitochondria in damaged rabbit myocardium].

Abstract

Alkaline phospholipases A were studied in rabbit myocardium under normal conditions and in heart impairment of various etiology. In mitochondrial fraction activity of phospholipase A was increased with elevation of Ca2+ concentration, while the enzyme was Ca2(+)-independent in lysosomes. Hemodynamic overloading of heart, acute local myocardial ischemia and diphtheritic intoxication led to an increase (2-4-fold) of mitochondrial phospholipases A activity with simultaneous decrease of the enzymatic activity in lysosomal membranes.

• Authors: L V Efimova
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1990 Nov-Dec Vol. 36 Issue 6 Pg. 34-6 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' shchelochnykh fosfolipaz A lizosom i mitokhondriĭ v povrezhdennom miokarde krolikov.
• PMID: 2075719 (Publication Type: Journal Article)

Chemical References

• Phosphatidylcholines
• Phospholipases A
• Calcium

Topics

• Animals
• Calcium (metabolism)
• Hydrogen-Ion Concentration
• Hydrolysis
• Lysosomes (enzymology)
• Mitochondria, Heart (enzymology)
• Myocardium (enzymology, pathology)
• Phosphatidylcholines (metabolism)
• Phospholipases A (metabolism)
• Rabbits