An open multicentre study of the efficacy and tolerance of cefodizime 1 g bd intravenously or intramuscularly in lower respiratory tract infections.

Abstract

The efficacy and tolerance of cefodizime in lower respiratory tract infections in hospitalized adults was evaluated in an open, non-comparative multicentre trial. Cefodizime (HR 221), was administered as a dose of 1 g by slow iv or im injection every 12 h (2 g daily) to 301 hospitalized patients aged 18-91 years. The mean duration of treatment was 10 +/- 3 days (median 9, range 1.23). All 301 patients were evaluable for tolerance, 270 were evaluable for clinical efficacy, and 204 were evaluable for bacteriological efficacy. A satisfactory clinical response was achieved in 87.8% (237/270) of patients and a satisfactory bacteriological response in 90.2% (184/204). Of the patients given the drug iv, 3.9% (6/153) had pain at the site of the injection compared with 7.4% (11/148) of those given the drug im. Tolerance was good; only five patients experienced an adverse reaction, and a relationship with cefodizime was considered probable in four of these cases. Haematological, hepatic and renal function tests revealed 27 abnormalities, all considered to have a doubtful relationship with treatment.

• Authors: J P Sollet
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 26 Suppl C Pg. 103-10 (Nov 1990) ISSN: 0305-7453 [Print] England
• PMID: 2074244 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Cefotaxime
• cefodizime

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Cefotaxime (adverse effects, analogs & derivatives, therapeutic use)
• Female
• Humans
• Injections, Intramuscular
• Injections, Intravenous
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy, microbiology)