Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats.

Abstract

Pancreatic islet cell tumors were induced in 38 of 44 male Wistar rats (86%), which survived 9 to 14 months following the various treatment schedules. A single i.v. injection of streptozotocin alone, 30, 40, 50, or 65 mg/kg of body weight produced adenomas of pancreatic islet cells in 8 of 9 (89%), 6 of 7 (86%), 2 of 4 (50%), and 1 of 2 rats (50%), respectively. The neoplasms were seen in all of the 8 rats given a single i.p. injection of picolinamide, 250 mg/kg of body weight, 15 min before a single i.v. injection of streptozotocin, 65 mg/kg of body weight. Among the 14 rats given a single i.p. injection of nicotinamide, 500 mg/kg of body weight, 15 min before a single i.v. injection of streptozotocin, 65 mg/kg of body weight, 13 rats (95%) developed pancreatic islet cell tumors. Renal tumors were seen in only 3 rats treated with streptozotocin and nicotinamide. None of rats used in this study developed hepatic tumors. This study demonstrates that steptozotocin, even in a dose of 30 mg/kg of body weight, has an exceedingly marked tumorigenic action on the rat pancreas, while it has little effect on the kidney and no effect on the liver.

• Authors: T Kazumi, G Yoshino, S Fujii, S Baba
• Journal: Cancer research (Cancer Res) Vol. 38 Issue 7 Pg. 2144-7 (Jul 1978) ISSN: 0008-5472 [Print] United States
• PMID: 207424 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Niacinamide
• Streptozocin

Topics

• Adenoma, Islet Cell (chemically induced, pathology)
• Animals
• Carcinogens
• Kidney Neoplasms (chemically induced)
• Liver (drug effects)
• Male
• Neoplasms, Experimental (chemically induced)
• Niacinamide (toxicity)
• Pancreatic Neoplasms (chemically induced, pathology)
• Rats
• Streptozocin (administration & dosage, toxicity)