Prognostic value of health-related quality-of-life parameters in early-stage breast cancer: an 8-year follow-up study.

Abstract

OBJECTIVE:

The purpose was to investigate whether self-reported health-related quality-of-life (HRQOL) parameters at time of diagnosis and/or 1-year follow-up are prognostic for disease-free survival (DFS) in early-stage breast cancer patients.

METHODS:

Data from 195 women, diagnosed with early-stage breast cancer, who had filled in the EORTC QLQ-C30 and the Hospital Anxiety and Depression Scale (HADS) at time of diagnosis and 1 year after surgery, were analyzed.

RESULTS:

After a median follow-up of 8.2 years (range 0.09-9.45), 27 (14.1%) deaths and 22 (11.5%) recurrences were observed. Using Cox multivariate regression analysis, appetite loss reported 1-year following surgery (HR 2.92, 95% CI 1.50-5.66), p=0.002) was significantly predictive for shorter DFS, even after controlling for age and depression. None of the clinical or biological prognostic factors was found to have a confounding effect.

CONCLUSION:

The findings indicate that loss of appetite probably is of prognostic value in addition to well-recognized clinical and biological data, in early-stage breast cancer.

• Authors: Inger Schou Bredal, Leiv Sandvik, Rolf Karesen, Oivind Ekeberg
• Journal: Psycho-oncology (Psychooncology) Vol. 20 Issue 10 Pg. 1102-7 (Oct 2011) ISSN: 1099-1611 [Electronic] England
• PMID: 20737644 (Publication Type: Journal Article)
• Copyright: 2010 John Wiley & Sons, Ltd.

Topics

• Adult
• Age Factors
• Aged
• Appetite
• Breast Neoplasms (diagnosis, mortality, psychology)
• Depression (etiology, psychology)
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Multivariate Analysis
• Prognosis
• Proportional Hazards Models
• Psychiatric Status Rating Scales
• Quality of Life (psychology)
• Regression Analysis
• Survival Analysis
• Young Adult