Abstract | OBJECTIVES:
Chronic pancreatitis (CP) is associated with risk factors that may negatively impact bone and mineral metabolism. The important clinical end point of osteoporosis is "low- trauma" fracture. The purpose of this study was to examine the prevalence of "low- trauma" fracture in patients with CP, compared with fracture rates in "high-risk" gastrointestinal (GI) illnesses, for which metabolic bone disease screening guidelines are in place. METHODS: This is a retrospective cohort database study examining patients with CP and "high-risk" GI illnesses seen at a single tertiary care center. Time points ranged between 31 July 1998 and 31 July 2008. The main outcome measure was "low- trauma" fracture prevalence using specific International Classification of Diseases, Ninth Revision, Clinical Modification fracture codes. RESULTS: A total of 3,192 CP patients and 1,461,207 non-CP patients were included in the study. The fracture prevalence (patients with fracture per total patients) was as follows: controls, 1.1% (16,208/1,436,699); Crohn's disease, 3.0% (182/6057); CP, 4.8% (154/3192); cirrhosis, 4.8% (805/16,658); celiac disease, 5.0% (74/1480); and postgastrectomy, 5.4% (17/313). Prevalence for each group was statistically greater than controls (P<0.001). CP fracture prevalence was greater than controls (P<0.001) and Crohn's disease (P<0.001), and comparable with the remaining "high-risk" GI illness groups (P>0.05). The odds of fracture (odds ratio (OR), 95% confidence interval (CI)) compared with controls, adjusted for age, gender, and race was: CP 2.4 (2.1, 2.9); Crohn's disease 1.7 (1.5, 2.0); gastrectomy 2.5 (1.5, 4.1); cirrhosis 2.6 (2.4, 2.7); and celiac disease 2.7 (2.1, 3.4). The odds of fracture for each disease group were statistically greater than controls (P<0.0001). CONCLUSIONS: The prevalence of low- trauma fracture in CP patients is comparable with or higher than that of "high-risk" GI illnesses, for which osteoporosis screening guidelines exist.
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Authors | April S Tignor, Bechien U Wu, Tom L Whitlock, Rocio Lopez, Kathryn Repas, Peter A Banks, Darwin Conwell |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 105
Issue 12
Pg. 2680-6
(Dec 2010)
ISSN: 1572-0241 [Electronic] United States |
PMID | 20736937
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Adult
- Aged
- Chi-Square Distribution
- Female
- Fractures, Bone
(epidemiology, etiology)
- Fractures, Spontaneous
(epidemiology, etiology)
- Humans
- Male
- Massachusetts
(epidemiology)
- Middle Aged
- Osteoporosis
(epidemiology, etiology)
- Pancreatitis, Chronic
(complications)
- Prevalence
- Retrospective Studies
- Risk Factors
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