Abstract | BACKGROUND: RESULTS: Blood from a 3-week-old newborn and from his parents was sent to our laboratory because of suspicion of NAIN. Granulocyte-specific antibodies were present in the maternal antiserum and reactive with the paternal granulocytes. The specificity of the maternal alloantibodies was shown to be anti-HNA-5a by the monoclonal antibody immobilization of granulocyte antigens assay. The mother was genotyped HNA-5a negative, and the father was genotyped homozygous HNA-5a positive. CONCLUSION:
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Authors | Leendert Porcelijn, Floor Abbink, Loes Terraneo, Laura Onderwater-vd Hoogen, Elly Huiskes, Masja de Haas |
Journal | Transfusion
(Transfusion)
Vol. 51
Issue 3
Pg. 574-7
(Mar 2011)
ISSN: 1537-2995 [Electronic] United States |
PMID | 20735765
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2010 American Association of Blood Banks. |
Chemical References |
- 5a antigen
- Immunoglobulin G
- Isoantibodies
- Isoantigens
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Topics |
- Adult
- Antibody Specificity
- Female
- Humans
- Immunoglobulin G
(blood)
- Infant, Newborn
- Isoantibodies
(blood)
- Isoantigens
(immunology)
- Male
- Neutropenia
(etiology)
- Neutrophils
(immunology)
- Pregnancy
|