Cytotoxic activity of quassinoids from Eurycoma longifolia.

Abstract

Twenty-four quassinoids isolated from Eurycoma longifolia Jack were investigated for their cytotoxicity against a panel of four different cancer cell lines, which includes three murine cell lines [colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), Lewis lung carcinoma (LLC)] and a human lung A549 adenocarcinoma (A549) cell line. Among the tested compounds, eurycomalactone (9) displayed the most potent activity against all the tested cell lines; colon 26-L5 (IC50 = 0.70 microM), B16-BL6 (IC50 = 0.59 microM), LLC (IC50 = 0.78 microM), and A549 (IC50 = 0.73 microM). These activities were comparable to clinically used anticancer agent doxorubicin (colon 26-L5, IC50 = 0.76 microM; B16-BL6, IC50 = 0.86 microM; LLC, IC50 = 0.80 microM; A549, IC50 = 0.66 microM).

• Authors: Katsunori Miyake, Feng Li, Yasuhiro Tezuka, Suresh Awale, Shigetoshi Kadota
• Journal: Natural product communications (Nat Prod Commun) Vol. 5 Issue 7 Pg. 1009-12 (Jul 2010) ISSN: 1934-578X [Print] United States
• PMID: 20734929 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Quassins

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Drug Screening Assays, Antitumor
• Eurycoma (chemistry)
• Humans
• Mice
• Molecular Structure
• Quassins (chemistry, pharmacology)