[Solifenacin in treatment of the overactive bladder syndrome--diagnosis, clinical management and results].

Abstract

UNLABELLED:

The overactive bladder syndrome (OAB) is a pathological condition that affects millions of people round the world. Its incidence increases with ageing. The main therapeutic option for OAB nowadays is anti-muscarinic drug therapy.

AIM:

To define and implement the diagnostic criteria, clinical guidelines in our country and to evaluate the results of Solifenacin therapy in patients with OAB.

MATERIAL AND METHODS:

Along a three years period (2006-2009) 163 OAB patients were analyzed followed and treated. In our group of patients 106 (65.2%) are females and 57 (34.8%)--males. The diagnosis is based mainly on the complaints of the patient, evaluated thoroughly with a detail anamnesis and questionnaires. Urodynamic studies were performed In some of the patients. The efficacy of Solifenacin therapy has been validated with the same methods used in SUNRISE and VENUS studies.

RESULTS AND DISCUSSION:

The mean age of female patients in our group is 63.8 years, and 65.6 years for males. The most commonly observed symptoms of OAB are urgency--88.3% and frequency--92%. Urge-incontinence is observed in 48.8% of the cases. Therapy with Solifenacin 5 and 10 mg has alleviated urgency in 82% and urge-incontinence in 88.9%. Mean number of pads used for 24 hours has decreased from 2.6 to 0.4 after therapy.

CONCLUSION:

Urgency is the main mandatory symptom for the diagnosis OAB. Therapy with Solifenacin 5 and 10 mg guarantees very good clinical results, and high degree of compliance of the patients.

• Authors: Ch Slavov, E Popov, S Slavov, R Dimitrov, N Doganov, T Chernev
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Sofiia)) Vol. 49 Issue 3 Pg. 16-21 ( 2010) ISSN: 0324-0959 [Print] Bulgaria
• PMID: 20734651 (Publication Type: English Abstract, Journal Article)

Chemical References

• Muscarinic Antagonists
• Quinuclidines
• Tetrahydroisoquinolines
• Solifenacin Succinate

Topics

• Aged
• Female
• Humans
• Male
• Middle Aged
• Muscarinic Antagonists (therapeutic use)
• Quinuclidines (therapeutic use)
• Solifenacin Succinate
• Tetrahydroisoquinolines (therapeutic use)
• Urinary Bladder, Overactive (diagnosis, drug therapy)
• Urinary Incontinence (drug therapy)