Abstract | PURPOSE OF REVIEW:
Cachexia occurs in various inflammatory diseases and is characterized by weight loss and muscle wasting. Pro-inflammatory cytokines modulate the activity of neuropeptides and hormones that control energy homeostasis and/or illness behaviors. This review summarizes recent (published within the past 18 months) literature regarding neuropeptides and hormones that have been implicated in the pathophysiology of cachexia, and that are likely to have therapeutic potential for preventing or reversing cachexia in various disease states. RECENT FINDINGS: SUMMARY: Promising outcomes from recent preclinical studies and/or early clinical trials with melanocortin receptor antagonists and ghrelin mimetics raise hopes that safe and effective anti- cachexia drugs will soon become available for widespread clinical use.
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Authors | Stephanie M Krasnow, Daniel L Marks |
Journal | Current opinion in supportive and palliative care
(Curr Opin Support Palliat Care)
Vol. 4
Issue 4
Pg. 266-71
(Dec 2010)
ISSN: 1751-4266 [Electronic] United States |
PMID | 20733497
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
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Topics |
- Animals
- Cachexia
(drug therapy, metabolism)
- Humans
- Neuropeptides
(metabolism, therapeutic use)
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