Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease.

Abstract

AIM:

To determine early brain changes in the distribution of an amyloid positron emission tomography (PET) probe, (11)C-labeled BF-227 or [(11)C]BF-227, in order to accurately predict the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD).

PATIENTS AND METHODS:

Amyloid plaque burden was evaluated using [(11)C]BF-227 PET in AD, MCI and aged normal controls. A voxel-based analysis of [(11)C]BF-227 PET images was performed to characterize the culprit brain lesion in patients with MCI who were destined to progress to AD, referred to as MCI converters (MCI-C). In addition, binding characteristics of BF-227 to amyloid deposits were examined using postmortem AD brain samples.

RESULTS:

Voxel-based statistical analyses of the BF-227 PET images clearly demonstrated an abnormal distribution of BF-227 mainly in the posterior association area in MCI-C and patients with AD. BF-227 uptake in the lateral temporal cortex was consistently observed in almost all MCI-C and patients with AD, and it distinguished MCI-C from MCI nonconverters. BF-227 binding strongly correlated with dense amyloid-β protein plaque density, but not with diffuse plaque density in the frontal cortex.

CONCLUSION:

BF-227 uptake in the lateral temporal cortex is a reliable indicator that can be used for predicting prognosis in patients with MCI.

• Authors: He Shao, Nobuyuki Okamura, Kentaro Sugi, Shozo Furumoto, Katsutoshi Furukawa, Manabu Tashiro, Ren Iwata, Hiroshi Matsuda, Yukitsuka Kudo, Hiroyuki Arai, Hiroshi Fukuda, Kazuhiko Yanai
• Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord) Vol. 30 Issue 2 Pg. 101-11 ( 2010) ISSN: 1421-9824 [Electronic] Switzerland
• PMID: 20733303 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 S. Karger AG, Basel.

Chemical References

• 2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole
• Amyloid
• Amyloid beta-Peptides
• Benzoxazoles
• Carbon Radioisotopes
• Thiazoles

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (diagnostic imaging, pathology, physiopathology)
• Amyloid (analysis)
• Amyloid beta-Peptides (analysis)
• Benzoxazoles
• Carbon Radioisotopes
• Cerebral Cortex (pathology)
• Data Interpretation, Statistical
• Disease Progression
• Educational Status
• Evidence-Based Medicine
• Female
• Humans
• Male
• Plaque, Amyloid (pathology)
• Positron-Emission Tomography
• Sex Factors
• Thiazoles
• Wechsler Scales